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Manuel Restrepo Restrepo, research dentist at CES University and member of the Research group on Hypomineralization of Molars and Incisors (HMI), won the recognition for

Dr. Manuel Restrepo Restrepo

Photography: Courtesy Manuel Restrepo Restrepo

best pediatric research with the work "Influence of the gene-gene interaction on the susceptibility of IMH".

The work was presented by Dr. Diego Bussaneli during the annual congress of the Brazilian Society of Pediatric Dentistry in October 2019, in Maceió, Brazil and also included the participation of researchers: Manuel Restrepo Restrepo, Aline Leite de Farias, Camila Fragelli , Fabiano Jeremias, Lourdes Santos-Pinto, Raquel Scarel-Caminaga, Alexandre Vieira and Rita de Cássia Loiola Cordeiro.

Hypomineralization of Molars and Incisors (HMI) is a permanent tooth defect that generally affects some back teeth and also teeth in the front part of children; they are white, cream, yellow and / or brown spots. For this reason, the objective of the research was to reveal what is the influence between the genes of the immune response and the developmental defect in the teeth, that is, if this defect is associated with some alterations in the genetic part.

“For this research we selected family nuclei that are basically composed of the child, the father, the mother and the biological siblings, in order to investigate whether there is an interaction between polymorphisms in genes of the immune response and in genes related to the formation of enamel, that is that is, if the alterations in the genetic part can act in conjunction with the genes that are responsible for the formation of enamel ”, explained the researcher dentist at the CES University, Manuel Restrepo Restrepo.

The researchers found that in addition to polymorphisms in genes directly related to enamel formation, polymorphisms in immune response genes can have a synergistic effect, increasing the risk of developing HMI.

“The solutions to this condition vary according to the individual characteristics of the patient and the tooth. There are preventive, restorative or complex treatments for severe cases that include tooth extraction and orthodontic treatment. These patients are generally more susceptible to dental caries because the teeth accumulate more plaque than the teeth that do not present this alteration ”, concluded the researcher.

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